Homo sapiens Gene: LRRFIP1
Summary
InnateDB Gene IDBG-84322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRFIP1
Gene Name leucine rich repeat (in FLII) interacting protein 1
Synonyms FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; TRIP;
Species Homo sapiens
Ensembl Gene ENSG00000124831
Encoded Proteins
leucine rich repeat (in FLII) interacting protein 1
leucine rich repeat (in FLII) interacting protein 1
leucine rich repeat (in FLII) interacting protein 1
leucine rich repeat (in FLII) interacting protein 1
leucine rich repeat (in FLII) interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LRRFIP1 interacts with and activates beta-catenin, which increases IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase EP300 to the IFN-beta enhanceosome via IRF3.
LRRFIP1 (GCF2) acts as a repressor and occupies the -308 site of the TNF-alpha promoter in cells that do not make TNF-alpha. Other proteins may bind to the promoter, particular to the -308 site to transition from repressed to active transcription.
LRRFIP1 is a regulator of toll-like receptor (TLR) pathway signaling and it co-localized with dsRNA in monocyte lysosomal structures.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:237627576-237813682
Strand Forward strand
Band q37.3
Transcripts
ENST00000244815 ENSP00000244815
ENST00000289175 ENSP00000289175
ENST00000308482 ENSP00000310109
ENST00000392000 ENSP00000375857
ENST00000420665 ENSP00000409431
ENST00000465870
ENST00000498053
ENST00000489295
ENST00000473815
ENST00000483443
ENST00000478958
ENST00000468950
ENST00000489603
ENST00000464608
ENST00000474195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
TSLP pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Immune System pathway
Cytosolic sensors of pathogen-associated DNA pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.638039
RefSeq NM_001137550 NM_001137552 NM_001137553 NM_004735 XM_005246136
HUGO
OMIM
CCDS CCDS2521 CCDS46551 CCDS46552 CCDS46553
HPRD 04460
IMGT
EMBL
GenPept
RNA Seq Atlas