InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LRRFIP1

Summary

InnateDB Gene

IDBG-84322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRFIP1

Gene Name

leucine rich repeat (in FLII) interacting protein 1

Synonyms

FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; TRIP

Species

Homo sapiens

Ensembl Gene

ENSG00000124831

Encoded Proteins

IDBP-84324

leucine rich repeat (in FLII) interacting protein 1

IDBP-84326

leucine rich repeat (in FLII) interacting protein 1

IDBP-84328

leucine rich repeat (in FLII) interacting protein 1

IDBP-246552

leucine rich repeat (in FLII) interacting protein 1

IDBP-389484

leucine rich repeat (in FLII) interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20453844

LRRFIP1 interacts with and activates beta-catenin, which increases IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase EP300 to the IFN-beta enhanceosome via IRF3.

PMID 16199883

LRRFIP1 (GCF2) acts as a repressor and occupies the -308 site of the TNF-alpha promoter in cells that do not make TNF-alpha. Other proteins may bind to the promoter, particular to the -308 site to transition from repressed to active transcription.

PMID 21102652

LRRFIP1 is a regulator of toll-like receptor (TLR) pathway signaling and it co-localized with dsRNA in monocyte lysosomal structures.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:237627576-237813682

Strand

Forward strand

Band

q37.3

Transcripts

ENST00000244815	ENSP00000244815
ENST00000289175	ENSP00000289175
ENST00000308482	ENSP00000310109
ENST00000392000	ENSP00000375857
ENST00000420665	ENSP00000409431
ENST00000465870
ENST00000498053
ENST00000489295
ENST00000473815
ENST00000483443
ENST00000478958
ENST00000468950
ENST00000489603
ENST00000464608
ENST00000474195

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008150	biological_process
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated