Homo sapiens Gene: CLPS
Summary
InnateDB Gene IDBG-84391.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLPS
Gene Name colipase, pancreatic
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137392
Encoded Proteins
colipase, pancreatic
colipase, pancreatic
colipase, pancreatic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:35794982-35797344
Strand Reverse strand
Band p21.31
Transcripts
ENST00000259938 ENSP00000259938
ENST00000622413 ENSP00000482919
ENST00000616014 ENSP00000483589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008047 enzyme activator activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0006629 lipid metabolic process
GO:0007586 digestion
GO:0007603 phototransduction, visible light
GO:0016042 lipid catabolic process
GO:0043085 positive regulation of catalytic activity
GO:0044241 lipid digestion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Retinoid metabolism and transport pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Digestion of dietary lipid pathway
Visual phototransduction pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Disease pathway
KEGG
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001252597 NM_001252598 NM_001832
HUGO
OMIM
CCDS CCDS4811 CCDS75437 CCDS75438
HPRD 00356
IMGT
EMBL
GenPept
RNA Seq Atlas