Homo sapiens Gene: FRAT1
Summary
InnateDB Gene IDBG-84511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRAT1
Gene Name frequently rearranged in advanced T-cell lymphomas
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165879
Encoded Proteins
frequently rearranged in advanced T-cell lymphomas
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:97319267-97321915
Strand Forward strand
Band q24.1
Transcripts
ENST00000371021 ENSP00000360060
ENST00000490980
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
Wnt pathway
REACTOME
truncated APC mutants destabilize the destruction complex pathway
Beta-catenin phosphorylation cascade pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt Q92837
TrEMBL
UniProt Splice Variant
Entrez Gene 10023
UniGene Hs.126057 Hs.721422
RefSeq NM_005479
HUGO HGNC:3944
OMIM 602503
CCDS CCDS7455
HPRD 03935
IMGT
EMBL AB074890 AL355490 BC034476 U58975
GenPept AAB97096 AAH34476 BAB86352 CAI40773
RNA Seq Atlas 10023