Version 5.4
| Homo sapiens Gene: FRAT1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-84511.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FRAT1 | ||||||||||||||||||
| Gene Name | frequently rearranged in advanced T-cell lymphomas | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000165879 | ||||||||||||||||||
| Encoded Proteins |
frequently rearranged in advanced T-cell lymphomas
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 10:97319267-97321915 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q24.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||
| NETPATH |
Wnt pathway
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| REACTOME |
Beta-catenin phosphorylation cascade pathway
Degradation of beta-catenin by the destruction complex pathway
truncated APC mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
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| KEGG |
Wnt signaling pathway pathway
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| INOH |
Wnt signaling pathway pathway
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| PID NCI |
Presenilin action in Notch and Wnt signaling
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| Cross-References | |||||||||||||||||||
| SwissProt | Q92837 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 10023 | ||||||||||||||||||
| UniGene | Hs.126057 Hs.721422 | ||||||||||||||||||
| RefSeq | NM_005479 | ||||||||||||||||||
| HUGO | HGNC:3944 | ||||||||||||||||||
| OMIM | 602503 | ||||||||||||||||||
| CCDS | CCDS7455 | ||||||||||||||||||
| HPRD | 03935 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB074890 AL355490 BC034476 U58975 | ||||||||||||||||||
| GenPept | AAB97096 AAH34476 BAB86352 CAI40773 | ||||||||||||||||||
| RNA Seq Atlas | 10023 | ||||||||||||||||||