Homo sapiens Gene: GLUD2
Summary
InnateDB Gene IDBG-84891.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLUD2
Gene Name glutamate dehydrogenase 2
Synonyms GDH2; GLUDP1;
Species Homo sapiens
Ensembl Gene ENSG00000182890
Encoded Proteins
glutamate dehydrogenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:121047588-121050080
Strand Forward strand
Band q24
Transcripts
ENST00000328078 ENSP00000327589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0005525 GTP binding
GO:0016491 oxidoreductase activity
GO:0043531 ADP binding
GO:0070728 leucine binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006536 glutamate metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006538 glutamate catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
D-Glutamine and D-glutamate metabolism pathway
Nitrogen metabolism pathway
Proximal tubule bicarbonate reclamation pathway
INOH
Glutamate Glutamine metabolism pathway
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P49448
TrEMBL Q9BSD0
UniProt Splice Variant
Entrez Gene 2747
UniGene Hs.368538
RefSeq NM_012084
HUGO HGNC:4336
OMIM 300144
CCDS CCDS14603
HPRD
IMGT
EMBL AC006144 AK313356 BC005111 BC050732 U08997 X66310
GenPept AAA20969 AAD05030 AAH05111 AAH50732 BAG36157 CAA46995
RNA Seq Atlas 2747