Version 5.4
Homo sapiens Gene: GLUD2
Summary
InnateDB Gene IDBG-84891.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLUD2
Gene Name glutamate dehydrogenase 2
Synonyms GDH2; GLUDP1
Species Homo sapiens
Ensembl Gene ENSG00000182890
Encoded Proteins
IDBP-84895
glutamate dehydrogenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:121047588-121050080
Strand Forward strand
Band q24
Transcripts
ENST00000328078 ENSP00000327589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0005525 GTP binding
GO:0016491 oxidoreductase activity
GO:0043531 ADP binding
GO:0070728 leucine binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006536 glutamate metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006538 glutamate catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00910
Nitrogen metabolism pathway
hsa00471
D-Glutamine and D-glutamate metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt P49448
TrEMBL Q9BSD0
UniProt Splice Variant
Entrez Gene 2747
UniGene Hs.368538
RefSeq NM_012084
HUGO HGNC:4336
OMIM 300144
CCDS CCDS14603
HPRD
IMGT
EMBL AC006144 AK313356 BC005111 BC050732 U08997 X66310
GenPept AAA20969 AAD05030 AAH05111 AAH50732 BAG36157 CAA46995
RNA Seq Atlas 2747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca