InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLUD2

Summary

InnateDB Protein

IDBP-84895.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLUD2

Protein Name

glutamate dehydrogenase 2

Synonyms

GDH2; GLUDP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000327589

InnateDB Gene

IDBG-84891 (GLUD2)

Protein Structure

UniProt Annotation

Function

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:22709669}.

Disease Associations

Tissue Specificity

Expressed in retina, testis and, at a lower level, brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004352	glutamate dehydrogenase (NAD+) activity
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity
GO:0005525	GTP binding
GO:0016491	oxidoreductase activity
GO:0043531	ADP binding
GO:0070728	leucine binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006536	glutamate metabolic process
GO:0006537	glutamate biosynthetic process
GO:0006538	glutamate catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase
IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain

PFAM

PF00208
PF02812

PRINTS

PR00082

PIRSF

SMART

SM00839

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt