Version 5.4
Homo sapiens Gene: MTCH1
Summary
InnateDB Gene IDBG-85191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTCH1
Gene Name mitochondrial carrier 1
Synonyms CGI-64; PIG60; PSAP; SLC25A49
Species Homo sapiens
Ensembl Gene ENSG00000137409
Encoded Proteins
IDBP-85193
mitochondrial carrier 1
IDBP-85195
mitochondrial carrier 1
IDBP-377205
mitochondrial carrier 1
IDBP-482564
mitochondrial carrier 1
IDBP-598406
mitochondrial carrier 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:36968141-36986298
Strand Reverse strand
Band p21.2
Transcripts
ENST00000373627 ENSP00000362730
ENST00000373616 ENSP00000362718
ENST00000418541 ENSP00000399187
ENST00000471737
ENST00000460219 ENSP00000419739
ENST00000492754
ENST00000538808 ENSP00000437660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009966 regulation of signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0045161 neuronal ion channel clustering
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024012
View Gene Order
ENSBTAG00000033453
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001271641 NM_014341 XM_005248979
HUGO
OMIM
CCDS CCDS4828 CCDS64411
HPRD 14787
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca