InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTCH1

Summary

InnateDB Protein

IDBP-85195.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTCH1

Protein Name

mitochondrial carrier 1

Synonyms

CGI-64; PIG60; PSAP; SLC25A49;

Species

Homo sapiens

Ensembl Protein

ENSP00000362718

InnateDB Gene

IDBG-85191 (MTCH1)

Protein Structure

UniProt Annotation

Function

Potential mitochondrial transporter. May play a role in apoptosis. {ECO:0000269PubMed:12377771}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed with a predominant expression in brain. {ECO:0000269PubMed:10551805}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009966	regulation of signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0045161	neuronal ion channel clustering

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NZJ7

PhosphoSite

PhosphoSite-Q9NZJ7

TrEMBL

A8YXX5

UniProt Splice Variant

Entrez Gene

23787

UniGene

RefSeq

NP_055156

HUGO

HGNC:17586

OMIM

610449

CCDS

CCDS4828

HPRD

14787

IMGT

EMBL

AF176006 AF189289 AF192559 AK022783 AK315067 AL122034 AY358519 AY947344 BC000702 BC006507 BC009962 BC110914 BC153873 CH471081

GenPept

AAD52644 AAF07936 AAF12793 AAH00702 AAH06507 AAH09962 AAI10915 AAI53874 AAQ88883 AAY57875 BAG37540 BAG51115 CAI23305 CAI23306 EAX03927 EAX03928 EAX03931