Version 5.4
Homo sapiens Gene: DIDO1
Summary
InnateDB Gene IDBG-85596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIDO1
Gene Name death inducer-obliterator 1
Synonyms BYE1; C20orf158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8
Species Homo sapiens
Ensembl Gene ENSG00000101191
Encoded Proteins
IDBP-85598
death inducer-obliterator 1
IDBP-85602
death inducer-obliterator 1
IDBP-85604
death inducer-obliterator 1
IDBP-85606
death inducer-obliterator 1
IDBP-85608
death inducer-obliterator 1
IDBP-239747
death inducer-obliterator 1
IDBP-239749
death inducer-obliterator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:62877738-62937952
Strand Reverse strand
Band q13.33
Transcripts
ENST00000266070 ENSP00000266070
ENST00000370371 ENSP00000359397
ENST00000370368 ENSP00000359394
ENST00000354665 ENSP00000346692
ENST00000370366 ENSP00000359391
ENST00000395343 ENSP00000378752
ENST00000395340 ENSP00000378749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038914
View Gene Order
ENSBTAG00000006002
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517172 Hs.653816 Hs.713343
RefSeq NM_001193369 NM_001193370 NM_022105 NM_033081 NM_080796 NM_080797
HUGO
OMIM
CCDS CCDS13508 CCDS13509 CCDS33506
HPRD 12752
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca