Version 5.4
Homo sapiens Protein: DIDO1
Summary
InnateDB Protein IDBP-85604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIDO1
Protein Name death inducer-obliterator 1
Synonyms BYE1; C20orf158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8;
Species Homo sapiens
Ensembl Protein ENSP00000359394
InnateDB Gene IDBG-85596 (DIDO1)
Protein Structure
UniProt Annotation
Function Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269PubMed:16127461}.Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269PubMed:16127461}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00651}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:23831028}. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
Protein Structure and Domains
PDB ID
InterPro IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00628
PRINTS
PIRSF
SMART SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BTC0
PhosphoSite PhosphoSite-Q9BTC0
TrEMBL
UniProt Splice Variant
Entrez Gene 11083
UniGene Hs.713343
RefSeq
HUGO HGNC:2680
OMIM 604140
CCDS CCDS13509
HPRD 12752
IMGT
EMBL AB002331 AK002127 AL035669 AL117379 AL133063 AY481571 AY481572 BC000770 BC004237 BC012757 BC014489 BC137177 CH471077
GenPept AAH00770 AAH04237 AAH14489 AAI37178 AAS49898 AAS49899 BAA20791 BAA92094 CAB61387 CAI95707 CAI95708 CAI95761 CAI95762 CAI95769 CAI95770 CAM28273 CAO03650 EAW75322 EAW75323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca