Homo sapiens Gene: ZFYVE27
Summary
InnateDB Gene IDBG-85688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE27
Gene Name zinc finger, FYVE domain containing 27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155256
Encoded Proteins
zinc finger, FYVE domain containing 27
zinc finger, FYVE domain containing 27
zinc finger, FYVE domain containing 27
zinc finger, FYVE domain containing 27
zinc finger, FYVE domain containing 27
zinc finger, FYVE domain containing 27
zinc finger, FYVE domain containing 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:97737121-97760907
Strand Forward strand
Band q24.2
Transcripts
ENST00000370613 ENSP00000359646
ENST00000337540 ENSP00000337993
ENST00000359980 ENSP00000353069
ENST00000357540 ENSP00000350148
ENST00000370610 ENSP00000359642
ENST00000393677 ENSP00000377282
ENST00000423811 ENSP00000409594
ENST00000462887
ENST00000481956
ENST00000477521
ENST00000473237
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0008219 cell death
GO:0031175 neuron projection development
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032584 growth cone membrane
GO:0055038 recycling endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q5T4F4
TrEMBL
UniProt Splice Variant
Entrez Gene 118813
UniGene Hs.523194 Hs.743469
RefSeq NM_001174121 NM_001002261 NM_001002262 NM_001174119 NM_001174120 NM_001174122 NM_144588 XM_005269502 XM_005269503 XM_005269504 XM_005269505 XM_005269506 XM_005269508 XM_005269509 XM_005269510 XM_005269511
HUGO HGNC:26559
OMIM 610243
CCDS CCDS53565 CCDS31263 CCDS31264 CCDS53562 CCDS53563 CCDS53564
HPRD 15735
IMGT
EMBL AK057481 AK074876 AK097945 AK296295 AK296588 AK299735 AL358938 AL834235 BC030621
GenPept AAH30621 BAB71506 BAC05200 BAC11260 BAH12306 BAH12390 BAH13112 CAD38913 CAI14270 CAI14271 CAI14272
RNA Seq Atlas 118813