InnateDB Protein
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IDBP-85696.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZFYVE27
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Protein Name
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zinc finger, FYVE domain containing 27
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353069
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InnateDB Gene
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IDBG-85688 (ZFYVE27)
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Protein Structure
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Function |
Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation. {ECO:0000269PubMed:17082457, ECO:0000269PubMed:19289470}.
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Subcellular Localization |
Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes at both dendrites and axons. {ECO:0000250}.
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Disease Associations |
Spastic paraplegia 33, autosomal dominant (SPG33) [MIM:610244]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. {ECO:0000269PubMed:16826525}. Note=The disease is caused by mutations affecting the gene represented in this entry. According to PubMed:18606302, the properties of the variant Val- 191 and its frequency in some populations raise doubts on the implication of that gene in the disease.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000306
FYVE zinc finger
IPR011011
Zinc finger, FYVE/PHD-type
IPR017455
Zinc finger, FYVE-related
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PFAM |
PF01363
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PRINTS |
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PIRSF |
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SMART |
SM00064
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TIGRFAMs |
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Modification |
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SwissProt |
Q5T4F4
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PhosphoSite |
PhosphoSite-Q5T4F4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
118813
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UniGene |
Hs.743469
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RefSeq |
NP_001002262
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HUGO |
HGNC:26559
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OMIM |
610243
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CCDS |
CCDS31264
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HPRD |
15735
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IMGT |
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EMBL |
AK057481
AK074876
AK097945
AK296295
AK296588
AK299735
AL358938
AL834235
BC030621
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GenPept |
AAH30621
BAB71506
BAC05200
BAC11260
BAH12306
BAH12390
BAH13112
CAD38913
CAI14270
CAI14271
CAI14272
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