InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDK11A

Summary

InnateDB Gene

IDBG-85824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK11A

Gene Name

cyclin-dependent kinase 11A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000008128

Encoded Proteins

IDBP-85703

cyclin-dependent kinase 11A

IDBP-85826

cyclin-dependent kinase 11A

IDBP-85828

cyclin-dependent kinase 11A

IDBP-85830

cyclin-dependent kinase 11A

IDBP-85834

cyclin-dependent kinase 11A

IDBP-226624

cyclin-dependent kinase 11A

IDBP-292367

cyclin-dependent kinase 11A

IDBP-475149

cyclin-dependent kinase 11A

IDBP-721604

IDBP-476837

cyclin-dependent kinase 11A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008] This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:1702730-1724324

Strand

Reverse strand

Band

p36.33

Transcripts

ENST00000358779	ENSP00000351629
ENST00000356937
ENST00000356200	ENSP00000348529
ENST00000378638	ENSP00000367905
ENST00000378633	ENSP00000367900
ENST00000357760	ENSP00000350403
ENST00000401096	ENSP00000383874
ENST00000404249	ENSP00000384442
ENST00000463652
ENST00000509982	ENSP00000422149
ENST00000460465	ENSP00000462289
ENST00000478901
ENST00000468397
ENST00000491311
ENST00000495016
ENST00000468800
ENST00000464748
ENST00000489300
ENST00000492390
ENST00000474916
ENST00000479362	ENSP00000423900
ENST00000498810
ENST00000487462

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001558	regulation of cell growth
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007067	mitotic nuclear division
GO:0050684	regulation of mRNA processing
GO:0051726	regulation of cell cycle