Homo sapiens Gene: CDK11A
Summary
InnateDB Gene IDBG-85824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK11A
Gene Name cyclin-dependent kinase 11A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000008128
Encoded Proteins
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008] This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1702730-1724324
Strand Reverse strand
Band p36.33
Transcripts
ENST00000358779 ENSP00000351629
ENST00000356937
ENST00000356200 ENSP00000348529
ENST00000378638 ENSP00000367905
ENST00000378633 ENSP00000367900
ENST00000357760 ENSP00000350403
ENST00000401096 ENSP00000383874
ENST00000404249 ENSP00000384442
ENST00000463652
ENST00000509982 ENSP00000422149
ENST00000460465 ENSP00000462289
ENST00000478901
ENST00000468397
ENST00000491311
ENST00000495016
ENST00000468800
ENST00000464748
ENST00000489300
ENST00000492390
ENST00000474916
ENST00000479362 ENSP00000423900
ENST00000498810
ENST00000487462
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001558 regulation of cell growth
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007067 mitotic nuclear division
GO:0050684 regulation of mRNA processing
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
Recruitment of mitotic centrosome proteins and complexes pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID BIOCARTA
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
PID NCI
Cross-References
SwissProt Q9UQ88
TrEMBL Q4VBY6 Q5QPQ9
UniProt Splice Variant
Entrez Gene 984
UniGene Hs.651228
RefSeq NM_024011 NM_033529 XM_006711065
HUGO HGNC:1730
OMIM 116951 176873
CCDS CCDS44042 CCDS44043
HPRD
IMGT
EMBL AF067518 AF067519 AF067520 AF067521 AF067522 AF067523 AF067524 AF067525 AF067526 AF067527 AF067528 AF067529 AF080689 AF080690 AF080691 AF080692 AF080693 AF080694 AF080695 AF080696 AF080697 AF092427 AF092428 AF105714 AL031282 BC094827 BC110905 U04819 U07704 U07705
GenPept AAA19585 AAA19594 AAA19595 AAC72083 AAC72084 AAC72085 AAC72086 AAC72087 AAC72088 AAC72089 AAC72090 AAC72091 AAC72092 AAC72093 AAC72094 AAC95297 AAC95298 AAC95299 AAC95300 AAC95302 AAC95303 AAH94827 AAI10906 CAI20032 CAI20033 CAI20034
RNA Seq Atlas 728642 984