InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDK11A

Summary

InnateDB Protein

IDBP-292367.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK11A

Protein Name

cyclin-dependent kinase 11A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384442

InnateDB Gene

IDBG-85824 (CDK11A)

Protein Structure

UniProt Annotation

Function

Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269PubMed:12501247, ECO:0000269PubMed:12624090}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. {ECO:0000269PubMed:8195233, ECO:0000269PubMed:9750192}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001558	regulation of cell growth
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007067	mitotic nuclear division
GO:0050684	regulation of mRNA processing
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt