Version 5.4
Homo sapiens Gene: DNAH8
Summary
InnateDB Gene IDBG-85894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAH8
Gene Name dynein, axonemal, heavy chain 8
Synonyms ATPase; hdhc9
Species Homo sapiens
Ensembl Gene ENSG00000124721
Encoded Proteins
IDBP-85896
dynein, axonemal, heavy chain 8
IDBP-85898
dynein, axonemal, heavy chain 8
IDBP-85900
dynein, axonemal, heavy chain 8
IDBP-241626
dynein, axonemal, heavy chain 8
IDBP-377667
dynein, axonemal, heavy chain 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:38715341-39030529
Strand Forward strand
Band p21.2
Transcripts
ENST00000327475 ENSP00000333363
ENST00000359357 ENSP00000352312
ENST00000373278 ENSP00000362375
ENST00000394393 ENSP00000377916
ENST00000449981 ENSP00000415331
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0001539 cilium or flagellum-dependent cell motility
GO:0006200 ATP catabolic process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005858 axonemal dynein complex
GO:0005874 microtubule
GO:0030286 dynein complex
GO:0097228 sperm principal piece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033826
View Gene Order
ENSBTAG00000014063
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520106
RefSeq NM_001206927 XM_006715004
HUGO
OMIM
CCDS CCDS75447
HPRD 04515
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca