InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VPS37A

Summary

InnateDB Gene

IDBG-8627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS37A

Gene Name

vacuolar protein sorting 37 homolog A (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000155975

Encoded Proteins

IDBP-8629

vacuolar protein sorting 37 homolog A (S. cerevisiae)

IDBP-361517

vacuolar protein sorting 37 homolog A (S. cerevisiae)

IDBP-479912

vacuolar protein sorting 37 homolog A (S. cerevisiae)

IDBP-476026

vacuolar protein sorting 37 homolog A (S. cerevisiae)

IDBP-485404

vacuolar protein sorting 37 homolog A (S. cerevisiae)

IDBP-479461

vacuolar protein sorting 37 homolog A (S. cerevisiae)

IDBP-480464

vacuolar protein sorting 37 homolog A (S. cerevisiae)

IDBP-481021

vacuolar protein sorting 37 homolog A (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:17246571-17302427

Strand

Forward strand

Band

p22

Transcripts

ENST00000324849	ENSP00000318629
ENST00000425020	ENSP00000412824
ENST00000519381	ENSP00000429227
ENST00000520140	ENSP00000428823
ENST00000518038	ENSP00000430456
ENST00000521829	ENSP00000429680
ENST00000521005	ENSP00000430933
ENST00000521976	ENSP00000429858
ENST00000521162
ENST00000520997
ENST00000519515

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0008219	cell death
GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0061024	membrane organization
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000813	ESCRT I complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0010008	endosome membrane
GO:0031902	late endosome membrane
GO:0043231	intracellular membrane-bounded organelle