Homo sapiens Gene: VPS37A
Summary
InnateDB Gene IDBG-8627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS37A
Gene Name vacuolar protein sorting 37 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155975
Encoded Proteins
vacuolar protein sorting 37 homolog A (S. cerevisiae)
vacuolar protein sorting 37 homolog A (S. cerevisiae)
vacuolar protein sorting 37 homolog A (S. cerevisiae)
vacuolar protein sorting 37 homolog A (S. cerevisiae)
vacuolar protein sorting 37 homolog A (S. cerevisiae)
vacuolar protein sorting 37 homolog A (S. cerevisiae)
vacuolar protein sorting 37 homolog A (S. cerevisiae)
vacuolar protein sorting 37 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:17246571-17302427
Strand Forward strand
Band p22
Transcripts
ENST00000324849 ENSP00000318629
ENST00000425020 ENSP00000412824
ENST00000519381 ENSP00000429227
ENST00000520140 ENSP00000428823
ENST00000518038 ENSP00000430456
ENST00000521829 ENSP00000429680
ENST00000521005 ENSP00000430933
ENST00000521976 ENSP00000429858
ENST00000521162
ENST00000520997
ENST00000519515
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008219 cell death
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0019082 viral protein processing
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0061024 membrane organization
GO:0075733 intracellular transport of virus
Cellular Component
GO:0000813 ESCRT I complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0010008 endosome membrane
GO:0031902 late endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
Synthesis And Processing Of GAG, GAGPOL Polyproteins pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
HIV Life Cycle pathway
HIV Infection pathway
Assembly Of The HIV Virion pathway
Budding and maturation of HIV virion pathway
Membrane binding and targetting of GAG proteins pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.343873 Hs.630607 Hs.634200
RefSeq NM_001145152 NM_152415 XM_005273401 XM_006716286
HUGO
OMIM
CCDS CCDS47811 CCDS6001
HPRD 13410
IMGT
EMBL
GenPept
RNA Seq Atlas