Version 5.4
Homo sapiens Gene: MOCS1
Summary
InnateDB Gene IDBG-86275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOCS1
Gene Name molybdenum cofactor synthesis 1
Synonyms MIG11; MOCOD; MOCODA
Species Homo sapiens
Ensembl Gene ENSG00000124615
Encoded Proteins
IDBP-86277
molybdenum cofactor synthesis 1
IDBP-86279
molybdenum cofactor synthesis 1
IDBP-86281
molybdenum cofactor synthesis 1
IDBP-86283
molybdenum cofactor synthesis 1
IDBP-86285
molybdenum cofactor synthesis 1
IDBP-377915
molybdenum cofactor synthesis 1
IDBP-377981
molybdenum cofactor synthesis 1
IDBP-484124
molybdenum cofactor synthesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:39899578-39934551
Strand Reverse strand
Band p21.2
Transcripts
ENST00000373195 ENSP00000362291
ENST00000373188 ENSP00000362284
ENST00000373186 ENSP00000362282
ENST00000340692 ENSP00000344794
ENST00000373181 ENSP00000362277
ENST00000425303 ENSP00000416478
ENST00000432280 ENSP00000410809
ENST00000473742
ENST00000487924 ENSP00000418315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005525 GTP binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0061597 cyclic pyranopterin monophosphate synthase activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0008152 metabolic process
GO:0032324 molybdopterin cofactor biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0019008 molybdopterin synthase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064120
View Gene Order
ENSBTAG00000010449
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00790
Folate biosynthesis pathway
hsa04122
Sulfur relay system pathway
INOH
PID NCI
Cross-References
SwissProt Q9NZB8
TrEMBL A0A024RD17 F8WCK1 Q9NP26 Q9NP27
UniProt Splice Variant
Entrez Gene 4337
UniGene Hs.718492
RefSeq NM_001075098 NM_005943
HUGO HGNC:7190
OMIM 603707
CCDS CCDS43460 CCDS4846
HPRD
IMGT
EMBL AF034374 AF214015 AF214022 AF214023 AJ224328 AJ293577 AJ293578 AJ293579 AJ404969 AK056740 AK300300 AL136089 AL357412 AL590999 AY423726 BC036839 CH471081
GenPept AAB87523 AAB87524 AAF67843 AAF67844 AAF67857 AAF67858 AAH36839 AAS00489 BAG51799 BAG62053 CAA11897 CAA11898 CAC44526 CAC44527 CAI20007 CAI20011 CAI20012 CAI20013 CAI20014 CAI20015 EAX04000 EAX04001
RNA Seq Atlas 4337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca