Homo sapiens Gene: MOCS1
Summary
InnateDB Gene IDBG-86275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOCS1
Gene Name molybdenum cofactor synthesis 1
Synonyms MIG11; MOCOD; MOCODA;
Species Homo sapiens
Ensembl Gene ENSG00000124615
Encoded Proteins
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:39899578-39934551
Strand Reverse strand
Band p21.2
Transcripts
ENST00000373195 ENSP00000362291
ENST00000373188 ENSP00000362284
ENST00000373186 ENSP00000362282
ENST00000340692 ENSP00000344794
ENST00000373181 ENSP00000362277
ENST00000425303 ENSP00000416478
ENST00000432280 ENSP00000410809
ENST00000473742
ENST00000487924 ENSP00000418315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005525 GTP binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0061597 cyclic pyranopterin monophosphate synthase activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0008152 metabolic process
GO:0032324 molybdopterin cofactor biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0019008 molybdopterin synthase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Folate biosynthesis pathway
Sulfur relay system pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.718492
RefSeq NM_001075098 NM_005943
HUGO
OMIM
CCDS CCDS43460 CCDS4846
HPRD 04749
IMGT
EMBL
GenPept
RNA Seq Atlas