Mus musculus Gene: Mocs1
Summary
InnateDB Gene IDBG-190104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mocs1
Gene Name molybdenum cofactor synthesis 1
Synonyms 3110045D15Rik; AI043170; AW536397;
Species Mus musculus
Ensembl Gene ENSMUSG00000064120
Encoded Proteins
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
molybdenum cofactor synthesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124615:
Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49428362-49455435
Strand Forward strand
Band C
Transcripts
ENSMUST00000024797 ENSMUSP00000024797
ENSMUST00000165390 ENSMUSP00000132371
ENSMUST00000173033 ENSMUSP00000133694
ENSMUST00000173362 ENSMUSP00000134265
ENSMUST00000174647 ENSMUSP00000133713
ENSMUST00000174268
ENSMUST00000172871 ENSMUSP00000134449
ENSMUST00000173430 ENSMUSP00000133761
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005525 GTP binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0061597 cyclic pyranopterin monophosphate synthase activity
Biological Process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0032324 molybdopterin cofactor biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0019008 molybdopterin synthase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Disease pathway
Metabolism pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective GIF causes intrinsic factor deficiency pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective CD320 causes methylmalonic aciduria pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Metabolism of vitamins and cofactors pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defects in vitamin and cofactor metabolism pathway
Defects in cobalamin (B12) metabolism pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Molybdenum cofactor biosynthesis pathway
Defective HLCS causes multiple carboxylase deficiency pathway
KEGG
Folate biosynthesis pathway
Sulfur relay system pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Defective GIF causes intrinsic factor deficiency pathway
Defects in cobalamin (B12) metabolism pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defects in vitamin and cofactor metabolism pathway
Defects in biotin (Btn) metabolism pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defective BTD causes biotidinase deficiency pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Defective CD320 causes methylmalonic aciduria pathway
Metabolism of water-soluble vitamins and cofactors pathway
Metabolism of vitamins and cofactors pathway
Molybdenum cofactor biosynthesis pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Disease pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
KEGG
Folate biosynthesis pathway
Sulfur relay system pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL G3UXJ3
UniProt Splice Variant
Entrez Gene 56738
UniGene
RefSeq NM_020042 NM_028464 XM_006524680 XM_006524681 XM_006524682
OMIM
CCDS CCDS50143 CCDS57100
HPRD
IMGT
MGI ID MGI:1928904
MGI Symbol Mocs1
EMBL AC165258
GenPept
RNA Seq Atlas 56738