Homo sapiens Gene: FPGS
Summary
InnateDB Gene IDBG-86502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FPGS
Gene Name folylpolyglutamate synthase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136877
Encoded Proteins
folylpolyglutamate synthase
folylpolyglutamate synthase
folylpolyglutamate synthase
folylpolyglutamate synthase
folylpolyglutamate synthase
folylpolyglutamate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:127794597-127814327
Strand Forward strand
Band q34.11
Transcripts
ENST00000373247 ENSP00000362344
ENST00000373228 ENSP00000362325
ENST00000373225 ENSP00000362322
ENST00000393706 ENSP00000377309
ENST00000431857 ENSP00000400007
ENST00000423577 ENSP00000406328
ENST00000479147
ENST00000479375
ENST00000488307
ENST00000481552
ENST00000460181
ENST00000475765
ENST00000496586
ENST00000469310
ENST00000497386
ENST00000488506
ENST00000489522
ENST00000467826
ENST00000473536
ENST00000475270
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0001889 liver development
GO:0006139 nucleobase-containing compound metabolic process
GO:0006730 one-carbon metabolic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0007420 brain development
GO:0009058 biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0031100 organ regeneration
GO:0044281 small molecule metabolic process
GO:0046655 folic acid metabolic process
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Folate biosynthesis pathway
INOH
Folate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.335084
RefSeq NM_001018078 NM_001288803 NM_004957
HUGO
OMIM
CCDS CCDS35148 CCDS35149 CCDS75905
HPRD 00642
IMGT
EMBL
GenPept
RNA Seq Atlas