InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FPGS

Summary

InnateDB Gene

IDBG-86502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FPGS

Gene Name

folylpolyglutamate synthase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000136877

Encoded Proteins

IDBP-86504

folylpolyglutamate synthase

IDBP-86510

folylpolyglutamate synthase

IDBP-86512

folylpolyglutamate synthase

IDBP-243059

folylpolyglutamate synthase

IDBP-381084

folylpolyglutamate synthase

IDBP-381085

folylpolyglutamate synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:127794597-127814327

Strand

Forward strand

Band

q34.11

Transcripts

ENST00000373247	ENSP00000362344
ENST00000373228	ENSP00000362325
ENST00000373225	ENSP00000362322
ENST00000393706	ENSP00000377309
ENST00000431857	ENSP00000400007
ENST00000423577	ENSP00000406328
ENST00000479147
ENST00000479375
ENST00000488307
ENST00000481552
ENST00000460181
ENST00000475765
ENST00000496586
ENST00000469310
ENST00000497386
ENST00000488506
ENST00000489522
ENST00000467826
ENST00000473536
ENST00000475270

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004326	tetrahydrofolylpolyglutamate synthase activity
GO:0005524	ATP binding
GO:0016874	ligase activity

Biological Process

GO:0001889	liver development
GO:0006139	nucleobase-containing compound metabolic process
GO:0006730	one-carbon metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0007420	brain development
GO:0009058	biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0031100	organ regeneration
GO:0044281	small molecule metabolic process
GO:0046655	folic acid metabolic process
GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009566

View Gene Order

ENSBTAG00000008994

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00790

Folate biosynthesis pathway

INOH

INOH website

Folate metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.335084

RefSeq

NM_001018078 NM_001288803 NM_004957

HUGO

OMIM

CCDS

CCDS35148 CCDS35149 CCDS75905

HPRD

00642

IMGT

EMBL

GenPept

RNA Seq Atlas