InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TREM2

Summary

InnateDB Gene

IDBG-86566.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TREM2

Gene Name

triggering receptor expressed on myeloid cells 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000095970

Encoded Proteins

IDBP-86568

triggering receptor expressed on myeloid cells 2

IDBP-86572

triggering receptor expressed on myeloid cells 2

IDBP-86574

triggering receptor expressed on myeloid cells 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21956652

TREM2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21956652

[Mus musculus] Trem2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells.

Entrez Gene

Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:41158506-41163186

Strand

Reverse strand

Band

p21.1

Transcripts

ENST00000373122	ENSP00000362214
ENST00000338469	ENSP00000342651
ENST00000373113	ENSP00000362205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006959	humoral immune response
GO:0007411	axon guidance
GO:0045087	innate immune response (InnateDB)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0097028	dendritic cell differentiation
GO:1903078	positive regulation of protein localization to plasma membrane
GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350	positive regulation of CD40 signaling pathway