InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trem2

Summary

InnateDB Gene

IDBG-189871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trem2

Gene Name

triggering receptor expressed on myeloid cells 2

Synonyms

TREM-2; Trem2a; Trem2b; Trem2c

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023992

Encoded Proteins

IDBP-189873

triggering receptor expressed on myeloid cells 2

IDBP-254323

triggering receptor expressed on myeloid cells 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21956652

Trem2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells.

InnateDB Annotation from Orthologs

Summary

PMID 21956652

[Homo sapiens] TREM2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells. (Demonstrated in mice)

Entrez Gene

Summary

The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer\'s disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:48346401-48354147

Strand

Forward strand

Band

Transcripts

ENSMUST00000024791	ENSMUSP00000024791
ENSMUST00000113237	ENSMUSP00000108863
ENSMUST00000132340
ENSMUST00000148545

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0097028	dendritic cell differentiation
GO:1903078	positive regulation of protein localization to plasma membrane
GO:1903082	positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350	positive regulation of CD40 signaling pathway