Mus musculus Gene: Trem2
Summary
InnateDB Gene IDBG-189871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trem2
Gene Name triggering receptor expressed on myeloid cells 2
Synonyms TREM-2; Trem2a; Trem2b; Trem2c;
Species Mus musculus
Ensembl Gene ENSMUSG00000023992
Encoded Proteins
triggering receptor expressed on myeloid cells 2
triggering receptor expressed on myeloid cells 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Trem2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] TREM2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells. (Demonstrated in mice)
Entrez Gene
Summary The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer\'s disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48346401-48354147
Strand Forward strand
Band C
Transcripts
ENSMUST00000024791 ENSMUSP00000024791
ENSMUST00000113237 ENSMUSP00000108863
ENSMUST00000132340
ENSMUST00000148545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0097110 scaffold protein binding
Biological Process
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0007165 signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097028 dendritic cell differentiation
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350 positive regulation of CD40 signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
Axon guidance pathway
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Osteoclast differentiation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
RANKL pathway
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
DAP12 signaling pathway
Other semaphorin interactions pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
DAP12 interactions pathway
KEGG
Osteoclast differentiation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.261623 Mm.439016
RefSeq NM_001272078 NM_031254
OMIM
CCDS CCDS28865 CCDS70825
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas