Homo sapiens Gene: SEMA4G
Summary
InnateDB Gene IDBG-86729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA4G
Gene Name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000095539
Encoded Proteins
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:100969518-100985871
Strand Forward strand
Band q24.31
Transcripts
ENST00000210633 ENSP00000210633
ENST00000370250 ENSP00000359270
ENST00000519649 ENSP00000428896
ENST00000521006 ENSP00000430881
ENST00000518124 ENSP00000430103
ENST00000518244
ENST00000517724 ENSP00000430175
ENST00000519756
ENST00000518948
ENST00000476171 ENSP00000429888
ENST00000484128
ENST00000613292 ENSP00000479499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0030154 cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 57715
UniGene Hs.591923 Hs.735152
RefSeq NM_001203244 NM_017893 XM_005270008 XM_005270009 XM_005270010
HUGO HGNC:10735
OMIM
CCDS CCDS55724 CCDS7501
HPRD 10218
IMGT
EMBL
GenPept
RNA Seq Atlas 57715