InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPC3

Summary

InnateDB Gene

IDBG-86754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPC3

Gene Name

glypican 3

Synonyms

DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1

Species

Homo sapiens

Ensembl Gene

ENSG00000147257

Encoded Proteins

IDBP-86756

glypican 3

IDBP-241869

glypican 3

IDBP-294897

glypican 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:133535745-133985895

Strand

Reverse strand

Band

q26.2

Transcripts

ENST00000370818	ENSP00000359854
ENST00000394299	ENSP00000377836
ENST00000406757	ENSP00000385307

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0060422	peptidyl-dipeptidase inhibitor activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001822	kidney development
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0008285	negative regulation of cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0009887	organ morphogenesis
GO:0009948	anterior/posterior axis specification
GO:0010171	body morphogenesis
GO:0010466	negative regulation of peptidase activity
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030282	bone mineralization
GO:0030316	osteoclast differentiation
GO:0030324	lung development
GO:0030513	positive regulation of BMP signaling pathway
GO:0035116	embryonic hindlimb morphogenesis
GO:0040008	regulation of growth
GO:0044281	small molecule metabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0045807	positive regulation of endocytosis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045926	negative regulation of growth
GO:0046326	positive regulation of glucose import
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060976	coronary vasculature development
GO:0072111	cell proliferation involved in kidney development
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development
GO:0072180	mesonephric duct morphogenesis
GO:0072203	cell proliferation involved in metanephros development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043202	lysosomal lumen
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome