InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPC3

Summary

InnateDB Protein

IDBP-86756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPC3

Protein Name

glypican 3

Synonyms

DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000359854

InnateDB Gene

IDBG-86754 (GPC3)

Protein Structure

UniProt Annotation

Function

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. {ECO:0000269PubMed:17549790}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.Secreted glypican-3: Secreted, extracellular space {ECO:0000250}.

Disease Associations

Simpson-Golabi-Behmel syndrome 1 (SGBS1) [MIM:312870]: A condition characterized by pre- and postnatal overgrowth (gigantism), facial dysmorphism and a variety of inconstant visceral and skeletal malformations. Characteristic dysmorphic features include macrocephaly with coarse, distinctive facies with a large protruding jaw, broad nasal bridge and cleft palate. Cardiac defects are frequent. {ECO:0000269PubMed:10814714}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0060422	peptidyl-dipeptidase inhibitor activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0009653	anatomical structure morphogenesis
GO:0010466	negative regulation of peptidase activity
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0044281	small molecule metabolic process
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome