InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC25A25

Summary

InnateDB Gene

IDBG-87248.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A25

Gene Name

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000148339

Encoded Proteins

IDBP-87250

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

IDBP-87252

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

IDBP-87254

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

IDBP-87256

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

IDBP-381262

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

IDBP-483973

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

IDBP-480803

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:128068201-128109245

Strand

Forward strand

Band

q34.11

Transcripts

ENST00000373069	ENSP00000362160
ENST00000373068	ENSP00000362159
ENST00000373066	ENSP00000362157
ENST00000373064	ENSP00000362155
ENST00000445012
ENST00000432073	ENSP00000410053
ENST00000472769	ENSP00000419685
ENST00000466983	ENSP00000418600

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0002021	response to dietary excess
GO:0014823	response to activity
GO:0032094	response to food
GO:0035264	multicellular organism growth
GO:0043010	camera-type eye development
GO:0045333	cellular respiration
GO:0046034	ATP metabolic process
GO:0060612	adipose tissue development
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026819

View Gene Order

ENSBTAG00000011912

Not yet available

Cross-References

SwissProt

TrEMBL

F8WEY9

UniProt Splice Variant

Entrez Gene

114789

UniGene

Hs.5476

RefSeq

NM_001006641 NM_001006642 NM_001265614 NM_052901 XM_005251688 XM_006716948 XM_006716949

HUGO

HGNC:20663

OMIM

608745

CCDS

CCDS35151 CCDS48031 CCDS59146 CCDS6890

HPRD

10573

IMGT

EMBL

AL360268 AL590708

GenPept

RNA Seq Atlas

114789