InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A25

Summary

InnateDB Protein

IDBP-87252.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A25

Protein Name

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362159

InnateDB Gene

IDBG-87248 (SLC25A25)

Protein Structure

UniProt Annotation

Function

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. {ECO:0000269PubMed:15123600}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600}; Multi- pass membrane protein {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600}.

Disease Associations

Tissue Specificity

Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung. {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0002021	response to dietary excess
GO:0014823	response to activity
GO:0032094	response to food
GO:0035264	multicellular organism growth
GO:0043010	camera-type eye development
GO:0045333	cellular respiration
GO:0046034	ATP metabolic process
GO:0060612	adipose tissue development
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR002067 Mitochondrial carrier protein
IPR002167 Graves disease carrier protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00036
PF13202
PF13405
PF00153

PRINTS

PR00926
PR00928

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt