Version 5.4
Homo sapiens Gene: PEX6
Summary
InnateDB Gene IDBG-87508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX6
Gene Name peroxisomal biogenesis factor 6
Synonyms PAF-2; PAF2; PBD4A; PDB4B; PXAAA1
Species Homo sapiens
Ensembl Gene ENSG00000124587
Encoded Proteins
IDBP-87510
peroxisomal biogenesis factor 6
IDBP-87512
peroxisomal biogenesis factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42963870-42979220
Strand Reverse strand
Band p21.1
Transcripts
ENST00000304611 ENSP00000303511
ENST00000244546 ENSP00000244546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 11 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0032403 protein complex binding
GO:0042623 ATPase activity, coupled
Biological Process
GO:0006200 ATP catabolic process
GO:0006625 protein targeting to peroxisome
GO:0007031 peroxisome organization
GO:0008152 metabolic process
GO:0016561 protein import into peroxisome matrix, translocation
GO:0050821 protein stabilization
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002763
View Gene Order
ENSBTAG00000005532
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.656425
RefSeq NM_000287
HUGO
OMIM
CCDS CCDS4877
HPRD 03293
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca