Version 5.4
Homo sapiens Gene: PPP2R5D
Summary
InnateDB Gene IDBG-87570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R5D
Gene Name protein phosphatase 2, regulatory subunit B', delta
Synonyms B56D
Species Homo sapiens
Ensembl Gene ENSG00000112640
Encoded Proteins
IDBP-87572
protein phosphatase 2, regulatory subunit B', delta
IDBP-242232
protein phosphatase 2, regulatory subunit B', delta
IDBP-474895
protein phosphatase 2, regulatory subunit B', delta
IDBP-477386
protein phosphatase 2, regulatory subunit B', delta
IDBP-477132
protein phosphatase 2, regulatory subunit B', delta
IDBP-474415
protein phosphatase 2, regulatory subunit B', delta
IDBP-479597
protein phosphatase 2, regulatory subunit B', delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42984499-43012342
Strand Forward strand
Band p21.1
Transcripts
ENST00000230402 ENSP00000230402
ENST00000394110 ENSP00000377669
ENST00000485511 ENSP00000417963
ENST00000472118 ENSP00000420550
ENST00000461010 ENSP00000420674
ENST00000470467 ENSP00000419756
ENST00000467447
ENST00000482315
ENST00000486843 ENSP00000420529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006112 energy reserve metabolic process
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0016311 dephosphorylation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050790 regulation of catalytic activity
GO:0051403 stress-activated MAPK cascade
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059409
View Gene Order
ENSBTAG00000005533
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_12436
ERKs are inactivated pathway
REACT_12599
ERK/MAPK targets pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_1383
Glycolysis pathway
REACT_705
PP2A-mediated dephosphorylation of key metabolic factors pathway
REACT_1505
Integration of energy metabolism pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_11061
Signalling by NGF pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_111217
Metabolism pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_604
Hemostasis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04114
Oocyte meiosis pathway
hsa03015
mRNA surveillance pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
aurora_a_pathway
Aurora A signaling
ps1pathway
Presenilin action in Notch and Wnt signaling
aurora_b_pathway
Aurora B signaling
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533308
RefSeq NM_001270476 NM_006245 NM_180976 NM_180977
HUGO
OMIM
CCDS CCDS43464 CCDS4878 CCDS55002
HPRD 09039
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca