InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R5D

Summary

InnateDB Protein

IDBP-474895.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R5D

Protein Name

protein phosphatase 2, regulatory subunit B', delta

Synonyms

B56D;

Species

Homo sapiens

Ensembl Protein

ENSP00000417963

InnateDB Gene

IDBG-87570 (PPP2R5D)

Protein Structure

UniProt Annotation

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subcellular Localization

Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.

Disease Associations

Tissue Specificity

Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	56 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0006112	energy reserve metabolic process
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0016311	dephosphorylation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050790	regulation of catalytic activity
GO:0051403	stress-activated MAPK cascade