Version 5.4
Homo sapiens Gene: SRF
Summary
InnateDB Gene IDBG-87849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRF
Gene Name serum response factor (c-fos serum response element-binding transcription factor)
Synonyms MCM1
Species Homo sapiens
Ensembl Gene ENSG00000112658
Encoded Proteins
IDBP-87851
serum response factor (c-fos serum response element-binding transcription factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008]
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43171299-43181507
Strand Forward strand
Band p21.1
Transcripts
ENST00000265354 ENSP00000265354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 74 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0010736 serum response element binding
GO:0031490 chromatin DNA binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001764 neuron migration
GO:0001829 trophectodermal cell differentiation
GO:0001947 heart looping
GO:0002011 morphogenesis of an epithelial sheet
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002521 leukocyte differentiation
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007015 actin filament organization
GO:0007160 cell-matrix adhesion
GO:0007369 gastrulation
GO:0007507 heart development
GO:0007616 long-term memory
GO:0008285 negative regulation of cell proliferation
GO:0008306 associative learning
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0010669 epithelial structure maintenance
GO:0010735 positive regulation of transcription via serum response element binding
GO:0016337 single organismal cell-cell adhesion
GO:0021766 hippocampus development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0030036 actin cytoskeleton organization
GO:0030038 contractile actin filament bundle assembly
GO:0030155 regulation of cell adhesion
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0030336 negative regulation of cell migration
GO:0031175 neuron projection development
GO:0033561 regulation of water loss via skin
GO:0034097 response to cytokine
GO:0035855 megakaryocyte development
GO:0035912 dorsal aorta morphogenesis
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043149 stress fiber assembly
GO:0043589 skin morphogenesis
GO:0045059 positive thymic T cell selection
GO:0045214 sarcomere organization
GO:0045597 positive regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045987 positive regulation of smooth muscle contraction
GO:0046016 positive regulation of transcription by glucose
GO:0046716 muscle cell cellular homeostasis
GO:0048589 developmental growth
GO:0048666 neuron development
GO:0048821 erythrocyte development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051491 positive regulation of filopodium assembly
GO:0055003 cardiac myofibril assembly
GO:0060055 angiogenesis involved in wound healing
GO:0060218 hematopoietic stem cell differentiation
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060292 long term synaptic depression
GO:0060347 heart trabecula formation
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0061029 eyelid development in camera-type eye
GO:0070830 tight junction assembly
GO:0071333 cellular response to glucose stimulus
GO:0090009 primitive streak formation
GO:0090136 epithelial cell-cell adhesion
GO:0090398 cellular senescence
GO:1900222 negative regulation of beta-amyloid clearance
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015605
View Gene Order
ENSBTAG00000012777
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
ar_pathway
Coregulation of Androgen receptor activity
erbb1_downstream_pathway
ErbB1 downstream signaling
hdac_classii_pathway
Signaling events mediated by HDAC Class II
rhoa_pathway
RhoA signaling pathway
pdgfrapathway
PDGFR-alpha signaling pathway
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt P11831
TrEMBL A0A024RD16 F5H6V4
UniProt Splice Variant
Entrez Gene 6722
UniGene Hs.667244
RefSeq NM_001292001 NM_003131
HUGO HGNC:11291
OMIM 600589
CCDS CCDS4889
HPRD
IMGT
EMBL AL133375 AL355385 BC048211 BC052572 CH471081 J03161
GenPept AAA36647 AAH48211 AAH52572 CAI13785 CAI20207 EAX04161 EAX04162
RNA Seq Atlas 6722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca