InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRF

Summary

InnateDB Protein

IDBP-87851.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRF

Protein Name

serum response factor (c-fos serum response element-binding transcription factor)

Synonyms

MCM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000265354

InnateDB Gene

IDBG-87849 (SRF)

Protein Structure

UniProt Annotation

Function

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00251, ECO:0000269PubMed:19350017}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	74 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0010736	serum response element binding
GO:0031490	chromatin DNA binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001707	mesoderm formation
GO:0001764	neuron migration
GO:0001829	trophectodermal cell differentiation
GO:0001947	heart looping
GO:0002011	morphogenesis of an epithelial sheet
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002521	leukocyte differentiation
GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007015	actin filament organization
GO:0007160	cell-matrix adhesion
GO:0007369	gastrulation
GO:0007507	heart development
GO:0007616	long-term memory
GO:0008285	negative regulation of cell proliferation
GO:0008306	associative learning
GO:0009636	response to toxic substance
GO:0009725	response to hormone
GO:0010669	epithelial structure maintenance
GO:0010735	positive regulation of transcription via serum response element binding
GO:0016337	single organismal cell-cell adhesion
GO:0021766	hippocampus development
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
GO:0030036	actin cytoskeleton organization
GO:0030038	contractile actin filament bundle assembly
GO:0030155	regulation of cell adhesion
GO:0030168	platelet activation
GO:0030220	platelet formation
GO:0030336	negative regulation of cell migration
GO:0031175	neuron projection development
GO:0033561	regulation of water loss via skin
GO:0034097	response to cytokine
GO:0035855	megakaryocyte development
GO:0035912	dorsal aorta morphogenesis
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043149	stress fiber assembly
GO:0043589	skin morphogenesis
GO:0045059	positive thymic T cell selection
GO:0045214	sarcomere organization
GO:0045597	positive regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045987	positive regulation of smooth muscle contraction
GO:0046016	positive regulation of transcription by glucose
GO:0046716	muscle cell cellular homeostasis
GO:0048589	developmental growth
GO:0048666	neuron development
GO:0048821	erythrocyte development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051491	positive regulation of filopodium assembly
GO:0055003	cardiac myofibril assembly
GO:0060055	angiogenesis involved in wound healing
GO:0060218	hematopoietic stem cell differentiation
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060292	long term synaptic depression
GO:0060347	heart trabecula formation
GO:0060947	cardiac vascular smooth muscle cell differentiation
GO:0061029	eyelid development in camera-type eye
GO:0070830	tight junction assembly
GO:0071333	cellular response to glucose stimulus
GO:0090009	primitive streak formation
GO:0090136	epithelial cell-cell adhesion
GO:0090398	cellular senescence
GO:1900222	negative regulation of beta-amyloid clearance