Homo sapiens Gene: LDOC1
Summary
InnateDB Gene IDBG-88129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDOC1
Gene Name leucine zipper, down-regulated in cancer 1
Synonyms BCUR1; Mar7; Mart7;
Species Homo sapiens
Ensembl Gene ENSG00000182195
Encoded Proteins
leucine zipper, down-regulated in cancer 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:141175745-141177125
Strand Reverse strand
Band q27.1
Transcripts
ENST00000370526 ENSP00000359557
ENST00000460721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 45 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt O95751
TrEMBL
UniProt Splice Variant
Entrez Gene 23641
UniGene
RefSeq NM_012317
HUGO HGNC:6548
OMIM 300402
CCDS CCDS14672
HPRD
IMGT
EMBL AB019527 AL109799 BC003104 CR457088
GenPept AAH03104 BAA34364 CAC18891 CAG33369
RNA Seq Atlas 23641