Version 5.4
Homo sapiens Gene: NT5C2
Summary
InnateDB Gene IDBG-88327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NT5C2
Gene Name 5'-nucleotidase, cytosolic II
Synonyms cN-II; GMP; NT5B; PNT5; SPG45; SPG65
Species Homo sapiens
Ensembl Gene ENSG00000076685
Encoded Proteins
IDBP-88331
5'-nucleotidase, cytosolic II
IDBP-294537
5'-nucleotidase, cytosolic II
IDBP-385030
5'-nucleotidase, cytosolic II
IDBP-385032
5'-nucleotidase, cytosolic II
IDBP-385035
5'-nucleotidase, cytosolic II
IDBP-809824
5'-nucleotidase, cytosolic II
IDBP-809826
5'-nucleotidase, cytosolic II
IDBP-598494
5'-nucleotidase, cytosolic II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5\'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:103088017-103193306
Strand Reverse strand
Band q24.33
Transcripts
ENST00000343289 ENSP00000339479
ENST00000369857
ENST00000404739 ENSP00000383960
ENST00000421281 ENSP00000408112
ENST00000452156 ENSP00000396468
ENST00000458345 ENSP00000411330
ENST00000469228
ENST00000461461 ENSP00000474091
ENST00000470228
ENST00000487810
ENST00000481549
ENST00000470299 ENSP00000474247
ENST00000467380
ENST00000552185 ENSP00000447664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008253 5'-nucleotidase activity
GO:0046872 metal ion binding
GO:0050146 nucleoside phosphotransferase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006195 purine nucleotide catabolic process
GO:0008219 cell death
GO:0016310 phosphorylation
GO:0016311 dephosphorylation
GO:0017144 drug metabolic process
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025041
View Gene Order
ENSBTAG00000012858
Not yet available
Pathways
NETPATH
REACTOME
REACT_121388
Abacavir metabolism pathway
REACT_2086
Purine catabolism pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_121189
Abacavir transport and metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00760
Nicotinate and nicotinamide metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.599825 Hs.712711 Hs.733282 Hs.733563
RefSeq NM_001134373 NM_012229 XM_005269636 XM_005269639 XM_005269640 XM_005269641 XM_005269642 XM_005269643 XM_006717721 XM_006717723 XM_006717724
HUGO
OMIM
CCDS CCDS7544
HPRD 02686
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca