Version 5.4
Homo sapiens Gene: INA
Summary
InnateDB Gene IDBG-88396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INA
Gene Name internexin neuronal intermediate filament protein, alpha
Synonyms NEF5; NF-66; TXBP-1
Species Homo sapiens
Ensembl Gene ENSG00000148798
Encoded Proteins
IDBP-88398
internexin neuronal intermediate filament protein, alpha
IDBP-811893
internexin neuronal intermediate filament protein, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:103277163-103290351
Strand Forward strand
Band q24.33
Transcripts
ENST00000369849 ENSP00000358865
ENST00000616853 ENSP00000481793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0021762 substantia nigra development
GO:0030154 cell differentiation
GO:0045104 intermediate filament cytoskeleton organization
GO:0060052 neurofilament cytoskeleton organization
Cellular Component
GO:0005615 extracellular space
GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0036464 cytoplasmic ribonucleoprotein granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034336
View Gene Order
ENSBTAG00000002717
Not yet available
Cross-References
SwissProt
TrEMBL B4DE66
UniProt Splice Variant
Entrez Gene 9118
UniGene
RefSeq NM_032727
HUGO HGNC:6057
OMIM 605338
CCDS CCDS7545
HPRD
IMGT
EMBL AK293490
GenPept BAG56977
RNA Seq Atlas 9118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca