Homo sapiens Gene: MEOX2
Summary
InnateDB Gene IDBG-8863.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEOX2
Gene Name mesenchyme homeobox 2
Synonyms GAX; MOX2;
Species Homo sapiens
Ensembl Gene ENSG00000106511
Encoded Proteins
mesenchyme homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer\'s disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:15611212-15686812
Strand Reverse strand
Band p21.2
Transcripts
ENST00000262041 ENSP00000262041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001525 angiogenesis
GO:0001757 somite specification
GO:0007275 multicellular organismal development
GO:0007519 skeletal muscle tissue development
GO:0008015 blood circulation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060021 palate development
GO:0060173 limb development
GO:0070997 neuron death
Cellular Component
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P50222
TrEMBL A4D127 Q6FHY5
UniProt Splice Variant
Entrez Gene 4223
UniGene Hs.170355 Hs.702298
RefSeq NM_005924
HUGO HGNC:7014
OMIM 600535
CCDS CCDS34605
HPRD
IMGT
EMBL AC004452 AC005550 AK313386 BC017021 CH236948 CR536553 L36328 X82629
GenPept AAA58497 AAC06184 AAC33152 AAH17021 BAG36184 CAA57949 CAG38790 EAL24289
RNA Seq Atlas 4223