Version 5.4
Homo sapiens Gene: UBE4B
Summary
InnateDB Gene IDBG-88839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE4B
Gene Name ubiquitination factor E4B
Synonyms E4; HDNB1; UBOX3; UFD2; UFD2A
Species Homo sapiens
Ensembl Gene ENSG00000130939
Encoded Proteins
IDBP-88843
ubiquitination factor E4B
IDBP-88845
ubiquitination factor E4B
IDBP-88847
ubiquitination factor E4B
IDBP-721838
IDBP-722095
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10032832-10181239
Strand Forward strand
Band p36.22
Transcripts
ENST00000253251 ENSP00000253251
ENST00000377153 ENSP00000366358
ENST00000343090 ENSP00000343001
ENST00000462658
ENST00000475795
ENST00000470736 ENSP00000467258
ENST00000466379
ENST00000488228 ENSP00000468178
ENST00000487244
ENST00000465408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 77 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028960
View Gene Order
ENSBTAG00000010401
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593974 Hs.601781 Hs.720101 Hs.734290
RefSeq NM_001105562 NM_006048
HUGO
OMIM
CCDS CCDS110 CCDS41245
HPRD 11659
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca