Homo sapiens Gene: SORCS1
Summary
InnateDB Gene IDBG-88966.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORCS1
Gene Name sortilin-related VPS10 domain containing receptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108018
Encoded Proteins
sortilin-related VPS10 domain containing receptor 1
sortilin-related VPS10 domain containing receptor 1
sortilin-related VPS10 domain containing receptor 1
sortilin-related VPS10 domain containing receptor 1
sortilin-related VPS10 domain containing receptor 1
sortilin-related VPS10 domain containing receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:106573663-107164534
Strand Reverse strand
Band q25.1
Transcripts
ENST00000369698 ENSP00000358712
ENST00000263054 ENSP00000263054
ENST00000344440 ENSP00000345964
ENST00000452214 ENSP00000407769
ENST00000473866
ENST00000478809
ENST00000486192
ENST00000472196
ENST00000622431 ENSP00000477888
ENST00000612154 ENSP00000478065
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008188 neuropeptide receptor activity
Biological Process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591915
RefSeq NM_001013031 NM_001206569 NM_001206570 NM_001206571 NM_001206572 NM_052918
HUGO
OMIM
CCDS CCDS7559
HPRD 12098
IMGT
EMBL
GenPept
RNA Seq Atlas