Version 5.4
Homo sapiens Protein: SORCS1
Summary
InnateDB Protein IDBP-88970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORCS1
Protein Name sortilin-related VPS10 domain containing receptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263054
InnateDB Gene IDBG-88966 (SORCS1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Detected in fetal and infant brain and in fetal retina.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008188 neuropeptide receptor activity
Biological Process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000601 PKD domain
IPR006581 VPS10
PFAM PF00801
PRINTS
PIRSF
SMART SM00602
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WY21
PhosphoSite PhosphoSite-Q8WY21
TrEMBL
UniProt Splice Variant
Entrez Gene 114815
UniGene Hs.591915
RefSeq NP_443150
HUGO HGNC:16697
OMIM 606283
CCDS CCDS7559
HPRD 12098
IMGT
EMBL AB209142 AF284756 AL133395 AL160010 AL356255 AL356308 AL357333 AY099452 AY099453 BC131597 CH471066
GenPept AAI31598 AAL56667 AAM43811 AAM43812 BAD92379 CAH70582 CAH73442 CAI14367 CAI16407 CAI40753 CAI40754 CAI40755 EAW49583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca