Homo sapiens Gene: MAGEA2B
Summary
InnateDB Gene IDBG-89149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGEA2B
Gene Name melanoma antigen family A, 2B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183305
Encoded Proteins
melanoma antigen family A, 2B
melanoma antigen family A, 2B
melanoma antigen family A, 2B
melanoma antigen family A, 2B
melanoma antigen family A, 2B
melanoma antigen family A, 2B
melanoma antigen family A, 2B
melanoma antigen family A, 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008] This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:152714586-152718607
Strand Forward strand
Band q28
Transcripts
ENST00000331220 ENSP00000333487
ENST00000370293 ENSP00000359316
ENST00000409560 ENSP00000386463
ENST00000423993 ENSP00000395386
ENST00000447530 ENSP00000389223
ENST00000458057 ENSP00000389999
ENST00000422085 ENSP00000397216
ENST00000453150 ENSP00000413384
ENST00000492402
ENST00000497578
ENST00000467743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042826 histone deacetylase binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0033234 negative regulation of protein sumoylation
GO:0044257 cellular protein catabolic process
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0072331 signal transduction by p53 class mediator
GO:0090398 cellular senescence
GO:1901984 negative regulation of protein acetylation
Cellular Component
GO:0005634 nucleus
GO:0016605 PML body
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL B9A060 E7ENJ0 E7EP80 E7EQY6
UniProt Splice Variant
Entrez Gene 4101
UniGene Hs.713061 Hs.736992
RefSeq NM_153488 XM_005277839
HUGO HGNC:19340
OMIM 300173 300549
CCDS CCDS76046
HPRD 14347
IMGT
EMBL AF002997
GenPept
RNA Seq Atlas 266740 4101