InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAGEA2B

Summary

InnateDB Protein

IDBP-89155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGEA2B

Protein Name

melanoma antigen family A, 2B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000333487

InnateDB Gene

IDBG-89149 (MAGEA2B)

Protein Structure

UniProt Annotation

Function

Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269PubMed:16847267, ECO:0000269PubMed:17942928, ECO:0000269PubMed:20864041, ECO:0000269PubMed:22117195}.

Subcellular Localization

Nucleus. Nucleus, PML body.

Disease Associations

Tissue Specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0033234	negative regulation of protein sumoylation
GO:0044257	cellular protein catabolic process
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0072331	signal transduction by p53 class mediator
GO:0090398	cellular senescence
GO:1901984	negative regulation of protein acetylation