InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMC3

Summary

InnateDB Gene

IDBG-89416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMC3

Gene Name

structural maintenance of chromosomes 3

Synonyms

BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1

Species

Homo sapiens

Ensembl Gene

ENSG00000108055

Encoded Proteins

IDBP-89418

structural maintenance of chromosomes 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:110567691-110604636

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000361804	ENSP00000354720
ENST00000462899

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	129 [view]
Protein-Protein	125 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0036033	mediator complex binding
GO:0045502	dynein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006275	regulation of DNA replication
GO:0006281	DNA repair
GO:0007052	mitotic spindle organization
GO:0007062	sister chromatid cohesion
GO:0007067	mitotic nuclear division
GO:0007126	meiotic nuclear division
GO:0007165	signal transduction
GO:0019827	stem cell maintenance
GO:0032876	negative regulation of DNA endoreduplication
GO:0051276	chromosome organization

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0000800	lateral element
GO:0000922	spindle pole
GO:0005604	basement membrane
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008278	cohesin complex
GO:0016363	nuclear matrix
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex