Homo sapiens Protein: SMC3 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Protein | IDBP-89418.5 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | SMC3 | ||||||||||||||||||||||||||||
Protein Name | structural maintenance of chromosomes 3 | ||||||||||||||||||||||||||||
Synonyms | BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1; | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000354720 | ||||||||||||||||||||||||||||
InnateDB Gene | IDBG-89416 (SMC3) | ||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||
Function | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269PubMed:11076961, ECO:0000269PubMed:19907496}. | ||||||||||||||||||||||||||||
Subcellular Localization | Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser- 1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). {ECO:0000250}. | ||||||||||||||||||||||||||||
Disease Associations | Cornelia de Lange syndrome 3 (CDLS3) [MIM:610759]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. Cornelia de Lange syndrome type 3 is a mild form with absence of major structural anomalies. The phenotype in some instances approaches that of apparently non- syndromic mental retardation. {ECO:0000269PubMed:17273969}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||
InterPro |
IPR003395
RecF/RecN/SMC, N-terminal IPR010935 SMCs flexible hinge IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF02463
PF06470 |
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PRINTS | |||||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||||
SMART |
SM00968
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TIGRFAMs | |||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | Q9UQE7 | ||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UQE7 | ||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 9126 | ||||||||||||||||||||||||||||
UniGene | Hs.678733 | ||||||||||||||||||||||||||||
RefSeq | NP_005436 | ||||||||||||||||||||||||||||
HUGO | HGNC:2468 | ||||||||||||||||||||||||||||
OMIM | 606062 | ||||||||||||||||||||||||||||
CCDS | CCDS31285 | ||||||||||||||||||||||||||||
HPRD | 05829 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | AF020043 AF067163 AJ005015 AK289771 AL359260 CH471066 | ||||||||||||||||||||||||||||
GenPept | AAC14893 AAD32447 BAF82460 CAA06289 CAI16576 EAW49557 | ||||||||||||||||||||||||||||