Homo sapiens Gene: NCS1
Summary
InnateDB Gene IDBG-89459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCS1
Gene Name neuronal calcium sensor 1
Synonyms FLUP; FREQ;
Species Homo sapiens
Ensembl Gene ENSG00000107130
Encoded Proteins
neuronal calcium sensor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:130172578-130237304
Strand Forward strand
Band q34.11
Transcripts
ENST00000372398 ENSP00000361475
ENST00000493042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0010975 regulation of neuron projection development
GO:0045921 positive regulation of exocytosis
GO:0048015 phosphatidylinositol-mediated signaling
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0031045 dense core granule
GO:0031410 cytoplasmic vesicle
GO:0032580 Golgi cisterna membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.642946 Hs.714951 Hs.732368
RefSeq NM_001128826 NM_014286
HUGO
OMIM
CCDS CCDS6932
HPRD 04500
IMGT
EMBL
GenPept
RNA Seq Atlas