Version 5.4
Homo sapiens Gene: NCS1
Summary
InnateDB Gene IDBG-89459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCS1
Gene Name neuronal calcium sensor 1
Synonyms FLUP; FREQ
Species Homo sapiens
Ensembl Gene ENSG00000107130
Encoded Proteins
IDBP-89461
neuronal calcium sensor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:130172578-130237304
Strand Forward strand
Band q34.11
Transcripts
ENST00000372398 ENSP00000361475
ENST00000493042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0010975 regulation of neuron projection development
GO:0045921 positive regulation of exocytosis
GO:0048015 phosphatidylinositol-mediated signaling
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0031045 dense core granule
GO:0031410 cytoplasmic vesicle
GO:0032580 Golgi cisterna membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062661
View Gene Order
ENSBTAG00000008726
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P62166
TrEMBL A0A024R8B2
UniProt Splice Variant
Entrez Gene 23413
UniGene Hs.642946 Hs.714951 Hs.732368
RefSeq NM_001128826 NM_014286
HUGO HGNC:3953
OMIM 603315
CCDS CCDS6932
HPRD
IMGT
EMBL AF134479 AF186409 AL360004 BC004856 BQ880305 CH471090 X84048
GenPept AAF01804 AAH04856 AAP97256 CAA58867 CAI16951 EAW87926 EAW87927
RNA Seq Atlas 23413

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca