InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCS1

Summary

InnateDB Protein

IDBP-89461.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCS1

Protein Name

neuronal calcium sensor 1

Synonyms

FLUP; FREQ;

Species

Homo sapiens

Ensembl Protein

ENSP00000361475

InnateDB Gene

IDBG-89459 (NCS1)

Protein Structure

UniProt Annotation

Function

Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0010975	regulation of neuron projection development
GO:0045921	positive regulation of exocytosis
GO:0048015	phosphatidylinositol-mediated signaling
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0031045	dense core granule
GO:0031410	cytoplasmic vesicle
GO:0032580	Golgi cisterna membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome