Homo sapiens Gene: BGN
Summary
InnateDB Gene IDBG-89505.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BGN
Gene Name biglycan
Synonyms DSPG1; PG-S1; PGI; SLRR1A;
Species Homo sapiens
Ensembl Gene ENSG00000182492
Encoded Proteins
biglycan
biglycan
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..
Entrez Gene
Summary The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153494939-153509554
Strand Forward strand
Band q28
Transcripts
ENST00000331595 ENSP00000327336
ENST00000431891 ENSP00000402525
ENST00000472615
ENST00000480756
ENST00000492658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0001974 blood vessel remodeling
GO:0005975 carbohydrate metabolic process
GO:0008150 biological_process
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030198 extracellular matrix organization
GO:0030203 glycosaminoglycan metabolic process
GO:0030204 chondroitin sulfate metabolic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005622 intracellular
GO:0005796 Golgi lumen
GO:0009986 cell surface
GO:0030133 transport vesicle
GO:0031012 extracellular matrix
GO:0042383 sarcolemma
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Extracellular matrix organization pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
CS/DS degradation pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Chondroitin sulfate biosynthesis pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
ECM proteoglycans pathway
Defective B3GAT3 causes JDSSDHD pathway
Dermatan sulfate biosynthesis pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Endogenous TLR signaling
Cross-References
SwissProt P21810
TrEMBL A6NLG9 B4DDQ2 C9JKG1
UniProt Splice Variant
Entrez Gene 633
UniGene Hs.821
RefSeq NM_001711
HUGO HGNC:1044
OMIM 301870
CCDS CCDS14721
HPRD
IMGT
EMBL AK094059 AK293289 BC002416 BC004244 BT007323 CH471172 J04599 M65152 M65153 U11686 U82695
GenPept AAA36009 AAA52287 AAC50117 AAH02416 AAH04244 AAP35987 BAG52806 BAG56813 EAW72863 EAW72864
RNA Seq Atlas 633