InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BGN

Summary

InnateDB Protein

IDBP-89507.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BGN

Protein Name

biglycan

Synonyms

DSPG1; PG-S1; PGI; SLRR1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000327336

InnateDB Gene

IDBG-89505 (BGN)

Protein Structure

UniProt Annotation

Function

May be involved in collagen fiber assembly. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in several connective tissues, especially in articular cartilages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0005975	carbohydrate metabolic process
GO:0008150	biological_process
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005622	intracellular
GO:0005796	Golgi lumen
GO:0009986	cell surface
GO:0030133	transport vesicle
GO:0031012	extracellular matrix
GO:0042383	sarcolemma
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan

PFAM

PF01462
PF00560
PF13504
PF13855

PRINTS

PIRSF

PIRSF002490

SMART

SM00013
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt