Homo sapiens Gene: SLC35B2
Summary
InnateDB Gene IDBG-89538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35B2
Gene Name solute carrier family 35, member B2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157593
Encoded Proteins
solute carrier family 35, member B2
solute carrier family 35, member B2
solute carrier family 35, member B2
solute carrier family 35, member B2
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:44254096-44257890
Strand Reverse strand
Band p21.1
Transcripts
ENST00000393812 ENSP00000377401
ENST00000393810 ENSP00000377399
ENST00000495706
ENST00000538577 ENSP00000443845
ENST00000537814 ENSP00000440340
ENST00000619636 ENSP00000483181
ENST00000615337 ENSP00000480681
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007165 signal transduction
GO:0030203 glycosaminoglycan metabolic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281 small molecule metabolic process
GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0055085 transmembrane transport
GO:1902559 3'-phospho-5'-adenylyl sulfate transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Mucopolysaccharidoses pathway
Transport of vitamins, nucleosides, and related molecules pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
Transport of nucleotide sugars pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
Phase II conjugation pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
Cytosolic sulfonation of small molecules pathway
Biological oxidations pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
Transport and synthesis of PAPS pathway
MPS IIIC - Sanfilippo syndrome C pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.182885 Hs.661026
RefSeq NM_001286509 NM_001286510 NM_001286511 NM_001286512 NM_001286513 NM_001286517 NM_001286519 NM_001286520 NM_178148
HUGO
OMIM
CCDS CCDS34462 CCDS69127 CCDS75462 CCDS75463
HPRD 11576
IMGT
EMBL
GenPept
RNA Seq Atlas