InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC35B2

Summary

InnateDB Gene

IDBG-89538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC35B2

Gene Name

solute carrier family 35, member B2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000157593

Encoded Proteins

IDBP-242882

solute carrier family 35, member B2

IDBP-242884

solute carrier family 35, member B2

IDBP-592685

solute carrier family 35, member B2

IDBP-587724

solute carrier family 35, member B2

IDBP-809479

solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2

IDBP-809480

solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:44254096-44257890

Strand

Reverse strand

Band

p21.1

Transcripts

ENST00000393812	ENSP00000377401
ENST00000393810	ENSP00000377399
ENST00000495706
ENST00000538577	ENSP00000443845
ENST00000537814	ENSP00000440340
ENST00000619636	ENSP00000483181
ENST00000615337	ENSP00000480681

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007165	signal transduction
GO:0030203	glycosaminoglycan metabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281	small molecule metabolic process
GO:0046963	3'-phosphoadenosine 5'-phosphosulfate transport
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:0055085	transmembrane transport
GO:1902559	3'-phospho-5'-adenylyl sulfate transmembrane transport