Homo sapiens Gene: ADRA2A
Summary
InnateDB Gene IDBG-89698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRA2A
Gene Name adrenoceptor alpha 2A
Synonyms ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32;
Species Homo sapiens
Ensembl Gene ENSG00000150594
Encoded Proteins
adrenergic, alpha-2A-, receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:111077163-111080907
Strand Forward strand
Band q25.2
Transcripts
ENST00000280155 ENSP00000280155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004938 alpha2-adrenergic receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0031692 alpha-1B adrenergic receptor binding
GO:0031696 alpha-2C adrenergic receptor binding
GO:0031996 thioesterase binding
GO:0032795 heterotrimeric G-protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051379 epinephrine binding
GO:0051380 norepinephrine binding
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0002526 acute inflammatory response
GO:0006112 energy reserve metabolic process
GO:0006260 DNA replication
GO:0006928 cellular component movement
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007565 female pregnancy
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0010700 negative regulation of norepinephrine secretion
GO:0019229 regulation of vasoconstriction
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032811 negative regulation of epinephrine secretion
GO:0032870 cellular response to hormone stimulus
GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042593 glucose homeostasis
GO:0042596 fear response
GO:0043268 positive regulation of potassium ion transport
GO:0043406 positive regulation of MAP kinase activity
GO:0044281 small molecule metabolic process
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045909 positive regulation of vasodilation
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0050796 regulation of insulin secretion
GO:0050892 intestinal absorption
GO:0050955 thermoception
GO:0050995 negative regulation of lipid catabolic process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051926 negative regulation of calcium ion transport
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070473 negative regulation of uterine smooth muscle contraction
GO:0071878 negative regulation of adrenergic receptor signaling pathway
GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO:0071882 phospholipase C-activating adrenergic receptor signaling pathway
GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway
GO:0090303 positive regulation of wound healing
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0043235 receptor complex
GO:0045202 synapse
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Class A/1 (Rhodopsin-like receptors) pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
G alpha (z) signalling events pathway
Platelet Aggregation (Plug Formation) pathway
Adrenoceptors pathway
Adrenaline signalling through Alpha-2 adrenergic receptor pathway
GPCR ligand binding pathway
Regulation of insulin secretion pathway
Metabolism pathway
Hemostasis pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P08913
TrEMBL
UniProt Splice Variant
Entrez Gene 150
UniGene Hs.249159 Hs.602746
RefSeq NM_000681
HUGO HGNC:281
OMIM 104210
CCDS CCDS7569
HPRD 00078
IMGT
EMBL AF262016 AF281308 AF284095 AF316894 AL158163 AY032736 BC035047 BC050414 DQ149926 DQ285607 EU332846 M18415 M23533
GenPept AAA51664 AAA51665 AAF91441 AAG00447 AAH35047 AAH50414 AAK01634 AAK26743 AAK51162 AAZ73101 ABB72683 ABY87535 CAH72817
RNA Seq Atlas 150