InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRA2A

Summary

InnateDB Gene

IDBG-89698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA2A

Gene Name

adrenoceptor alpha 2A

Synonyms

ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32

Species

Homo sapiens

Ensembl Gene

ENSG00000150594

Encoded Proteins

IDBP-89702

adrenergic, alpha-2A-, receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:111077163-111080907

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000280155

ENSP00000280155

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031692	alpha-1B adrenergic receptor binding
GO:0031696	alpha-2C adrenergic receptor binding
GO:0031996	thioesterase binding
GO:0032795	heterotrimeric G-protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0002526	acute inflammatory response
GO:0006112	energy reserve metabolic process
GO:0006260	DNA replication
GO:0006928	cellular component movement
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007265	Ras protein signal transduction
GO:0007266	Rho protein signal transduction
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0010700	negative regulation of norepinephrine secretion
GO:0019229	regulation of vasoconstriction
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0030335	positive regulation of cell migration
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032147	activation of protein kinase activity
GO:0032148	activation of protein kinase B activity
GO:0032811	negative regulation of epinephrine secretion
GO:0032870	cellular response to hormone stimulus
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042593	glucose homeostasis
GO:0042596	fear response
GO:0043268	positive regulation of potassium ion transport
GO:0043406	positive regulation of MAP kinase activity
GO:0044281	small molecule metabolic process
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045909	positive regulation of vasodilation
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0046676	negative regulation of insulin secretion
GO:0050796	regulation of insulin secretion
GO:0050892	intestinal absorption
GO:0050955	thermoception
GO:0050995	negative regulation of lipid catabolic process
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051926	negative regulation of calcium ion transport
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070473	negative regulation of uterine smooth muscle contraction
GO:0071878	negative regulation of adrenergic receptor signaling pathway
GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO:0071882	phospholipase C-activating adrenergic receptor signaling pathway
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway
GO:0090303	positive regulation of wound healing
GO:1901020	negative regulation of calcium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0043235	receptor complex
GO:0045202	synapse