InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRA2A

Summary

InnateDB Protein

IDBP-89702.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA2A

Protein Name

adrenergic, alpha-2A-, receptor

Synonyms

ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32;

Species

Homo sapiens

Ensembl Protein

ENSP00000280155

InnateDB Gene

IDBG-89698 (ADRA2A)

Protein Structure

UniProt Annotation

Function

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269PubMed:23105096}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23105096}; Multi-pass membrane protein {ECO:0000269PubMed:23105096}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031692	alpha-1B adrenergic receptor binding
GO:0031696	alpha-2C adrenergic receptor binding
GO:0031996	thioesterase binding
GO:0032795	heterotrimeric G-protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0002526	acute inflammatory response
GO:0006112	energy reserve metabolic process
GO:0006260	DNA replication
GO:0006928	cellular component movement
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007265	Ras protein signal transduction
GO:0007266	Rho protein signal transduction
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0010700	negative regulation of norepinephrine secretion
GO:0019229	regulation of vasoconstriction
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0030335	positive regulation of cell migration
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032147	activation of protein kinase activity
GO:0032148	activation of protein kinase B activity
GO:0032811	negative regulation of epinephrine secretion
GO:0032870	cellular response to hormone stimulus
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042593	glucose homeostasis
GO:0042596	fear response
GO:0043268	positive regulation of potassium ion transport
GO:0043406	positive regulation of MAP kinase activity
GO:0044281	small molecule metabolic process
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045909	positive regulation of vasodilation
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0046676	negative regulation of insulin secretion
GO:0050796	regulation of insulin secretion
GO:0050892	intestinal absorption
GO:0050955	thermoception
GO:0050995	negative regulation of lipid catabolic process
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051926	negative regulation of calcium ion transport
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070473	negative regulation of uterine smooth muscle contraction
GO:0071878	negative regulation of adrenergic receptor signaling pathway
GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO:0071882	phospholipase C-activating adrenergic receptor signaling pathway
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway
GO:0090303	positive regulation of wound healing
GO:1901020	negative regulation of calcium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0043235	receptor complex
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000995 Muscarinic acetylcholine receptor family
IPR001946 Alpha 2A adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00243
PR00558
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08913