Version 5.4
Homo sapiens Gene: CLIC5
Summary
InnateDB Gene IDBG-89803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC5
Gene Name chloride intracellular channel 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112782
Encoded Proteins
IDBP-89805
chloride intracellular channel 5
IDBP-89807
chloride intracellular channel 5
IDBP-592271
chloride intracellular channel 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:45898451-46080395
Strand Reverse strand
Band p21.1
Transcripts
ENST00000185206 ENSP00000185206
ENST00000339561 ENSP00000344165
ENST00000487396
ENST00000484572
ENST00000486570
ENST00000476852
ENST00000464137
ENST00000544153 ENSP00000439195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0002021 response to dietary excess
GO:0002024 diet induced thermogenesis
GO:0006810 transport
GO:0006821 chloride transport
GO:0007565 female pregnancy
GO:0007605 sensory perception of sound
GO:0008104 protein localization
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0050885 neuromuscular process controlling balance
GO:0060088 auditory receptor cell stereocilium organization
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023959
View Gene Order
ENSBTAG00000010244
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.485489 Hs.629445
RefSeq NM_001114086 NM_001256023 NM_016929 XM_006715115
HUGO
OMIM
CCDS CCDS47438 CCDS4914 CCDS59022
HPRD 06292
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca