Version 5.4
Mus musculus Gene: Clic5
Summary
InnateDB Gene IDBG-184858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clic5
Gene Name chloride intracellular channel 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000023959
Encoded Proteins
IDBP-184860
chloride intracellular channel 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112782:
This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:44188572-44280168
Strand Forward strand
Band B3
Transcripts
ENSMUST00000024755 ENSMUSP00000024755
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0002021 response to dietary excess
GO:0002024 diet induced thermogenesis
GO:0006821 chloride transport
GO:0007605 sensory perception of sound
GO:0008104 protein localization
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0050885 neuromuscular process controlling balance
GO:0060088 auditory receptor cell stereocilium organization
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112782
View Gene Order
ENSBTAG00000010244
Not yet available
Cross-References
SwissProt Q8BXK9
TrEMBL
UniProt Splice Variant
Entrez Gene 224796
UniGene Mm.37666
RefSeq NM_172621 XM_006524135
OMIM
CCDS CCDS28804
HPRD
IMGT
MGI ID MGI:1917912
MGI Symbol Clic5
EMBL AK046522 AK156849 BC064037
GenPept AAH64037 BAC32769 BAE33875
RNA Seq Atlas 224796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca